Research Institute for Electronic Science HOKKAIDO University Molecular Device Lab.

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Preparation and characterization of double-stranded DNA brushes via surface-initiated enzymatic polymerization
Hideyuki Mitomo, Satoshi Nakamura, Yasunobu Suzuki, Yasutaka Matsuo, Kenichi Niikura, Kuniharu Ijiro
J. Nanosci. Nanotechnol., accepted  

Formation of Plasmonic Vesicles through the Self-assembly of Sugar-terminated Fluorinated Oligo(ethylene glycol) Ligand-tethered Gold Nanoparticles
Jinjian Wei, Kenichi Niikura, Hideyuki Mitomo, Yasutaka Mastuo, Kuniharu Ijiro
J. Nanosci. Nanotechnol., accepted 

DNA Brush-Directed Vertical Alignment of Extensive Gold Nanorod Arrays with Controlled Density

Satoshi Nakamura, Hideyuki Mitomo, Miho Aizawa, Takeharu Tani, Yasutaka Mastuo, Kenichi Niikura, Andrew Pike, Masayuki Naya, Atsushi Shishido, Kuniharu Ijiro
ACS omega 2017, 2(5), 2208-2213.

pH-Responsive Co-assembly of Oligo(ethylene glycol)-Coated Gold Nanoparticles with External Anionic Polymers via Hydrogen Bonding
Yu Torii, Naotoshi Sugimura, Hideyuki Mitomo, Kenichi Niikura, and Kuniharu Ijiro
Langmuir., accepted  


Reverse Size Dependences of Triangular and Spherical Gold Nanoparticles on the Cellular Uptake
Katsuyuki Nambara, Kenichi Niikura, Hideyuki Mitomo, Takafumi Ninomiya, Chie Takeuchi, Jinjian Wei, Yasutaka Matsuo, and Kuniharu Ijiro,
Langmuir 201632, 12559-12567.

高分子論文集, 201673(2), 147-156

Yolk/Shell Assembly of Gold Nanoparticles by Size Segregation in Solution
Jinjian Wei, Kenichi Niikura, Takeshi Higuchi, Takashi Kimura, Hideyuki Mitomo, Hiroshi Jinnai, Yasumasa Joti, Yoshitaka Bessho, Yoshinori Nishino, Yasutaka Matsuo, and Kuniharu Ijiro,
J. Am. Chem. Soc. 2016, 138, 3274-3277

Fabrication of a Novel Cell Culture System using DNA-Grafted Substrates and DNase,
H. Mitomo, A. Eguchi, Y. Suzuki, Y. Matsuo, K. Niikura, K. Nakazawa, and K. Ijiro,
J. Biomed. Nanotechnol. 2016, 12, 286-295

High-yield halide-free synthesis of biocompatible Au nanoplates
Guoqing Wang, Shengyang Tao, Yiding Liu, Lei Guo, Guohui Qin, Kuniharu Ijiro, Mizuo Maeda and Yadong Yin
Chem. Commun. 2016, 52, 398-401

Active Gap SERS for the Sensitive Detection of Biomacromolecules with Plasmonic Nanostructures on Hydrogels
H. Mitomo, K. Horie, Y. Matsuo, K. Niikura, T. Tani, M. Naya, and K. Ijiro
Adv. Opt. Mater. 2016, 4, 259–263

Thermoresponsive Assembly of Gold Nanoparticles Coated with Oligo(Ethylene Glycol) Ligands with an Alkyl Head
Ryo Iida, Hideyuki Mitomo, Yasutaka Matsuo, Kenichi Niikura, and Kuniharu Ijiro
J. Phys. Chem. C 2016120, 15846-15854


Noncationic Rigid and Anisotropic Coiled-Coil Proteins Exhibit Cell-Penetration Activity
N. Nakayama, K. Hagiwara, Y. Ito, K. Ijiro, Y. Osada, and K. Sano
Langmuir 201531, 8218–8223

DNA-modulated photo-transformation of AgCl to silver nanoparticles: Visiting the formation mechanism
Guoqing Wang, Hideyuki Mitomo, Yasutaka Matsuo, Kenichi Niikura, and Kuniharu Ijiro
Journal of Colloid and Interface Science 2015, 452, 224-234

Synthesis of Janus-Like Gold Nanoparticles with Hydrophilic/Hydrophobic Faces by Surface Ligand Exchange and Their Self-Assemblies in Water
Ryo Iida, Hitoshi Kawamura, Kenichi Niikura, Takashi Kimura, Shota Sekiguchi, Yasumasa Joti, Yoshitaka Bessho, Hideyuki Mitomo, Yoshinori Nishino, and Kuniharu Ijiro
Langmuir 2015, 31, 4054-4062

Encapsulation of a Gold Nanoparticle in a DNA Origami Container
Akinori Kuzuya, Yuichi Ohya , Masafumi Kaino, Mirai Hashizume, Kazuki Matsumoto
Takeaki Uehara, Yasutaka Matsuo, Hideyuki Mitomo, Kenichi Niikura, Kuniharu Ijiro, Yuichi Ohya
Polymer Journal 2015, 47, 177-182

Superior Cell Penetration by a Rigid and Anisotropic Synthetic Protein
N. Nakayama, K. Hagiwara, Y. Ito, K. Ijiro, Y. Osada, and K. Sano
Langmuir 201531, 2826-2832

Enzymatic Synthesis of a DNA Triblock Copolymer that is Composed of Natural and Unnatural Nucleotides
Hideyuki Mitomo, Yukie Watanabe, Yasutaka Matsuo, Kenichi Niikura, Kuniharu Ijiro
Chem. Asian. J. 2015, 10, 455–460


Amphiphilic Gold Nanoparticles Displaying Flexible Bifurcated Ligands as a Carrier for siRNA Delivery into the Cell Cytosol
Kenichi Niikura, Kenya Kobayashi, Chie Takeuchi, Naoki Fujitani, Shuko Takahara,
Takafumi Ninomiya, Kyoji Hagiwara, Hideyuki Mitomo, Yoshihiro Ito, Yoshihito Osada,
Kuniharu Ijiro
ACS Appl. Mater. Interfaces 2014, 6, 22146–22154

Enhanced Cellular Uptake of Amphiphilic Gold Nanoparticles with Ester Functionality
Kenya Kobayashi, Kenichi Niikura, Chie Takeuchi, Shota Sekiguchi, Takafumi Ninomiya, Kyoji Hagiwara, Hideyuki Mitomo, Yoshihiro Ito, Yoshihito Osada and Kuniharu Ijiro
Chem. Commun. 2014, 50, 1265-1267

Chemically cross-linked microtubule assembly shows enhanced dynamic motions on kinesins
Ryuzo Kawamura, Ken-Ichi Sano, Kuniharu Ijiro, and Yoshihito Osada
RSC Advances 2014, 4, 32953-32959


Water transport mechanism through open capillaries analyzed by direct surface modifications on biological surfaces
Daisuke Ishii, Hiroko Horiguchi, Yuji Hirai, Hiroshi Yabu, Yasutaka Matsuo, Kuniharu Ijiro, Kaoru Tsujii, Tateo Shimozawa, Takahiko Hariyama & Masatsugu Shimomura
Scientific Reports, 2013, 3, 3024

Cysteine Residues in the Major Capsid Protein, Vp1, of the JC Virus Are Important for Protein Stability and Oligomer Formation
S. Kobayashi, T. Suzuki, M. Igarashi, Y. Orba, N. Ohtake, K. Nagakawa, K. Niikura, T. Kimura, H. Kasamatsu, and H. Sawa
PLOS ONE, 2013, 8(10), e76668

DNA-templated plasmonic Ag/AgCl nanostructures for molecular selective photocatalysis and photocatalytic inactivation of cancer cells
G. Wang, H. Mitomo, Y. Matsuo, N. Shimamoto, K. Niikura, and K. Ijiro
Journal of Materials Chemistry B, 2013, 1, 5899

三友秀之・渡辺雪江・松尾保孝・新倉謙一・居城邦治 高分子論文集, 70(7), 337-340 (2013)

Enhanced Photon Extraction from a Quantum Dot Induced by a Silver Microcolumnar Photon Reflector
Hidekazu Kumano, Hideaki Nakajima, Hitoshi Iijima, Satoru Odashima, Yasuhiro Matsuo, Kuniharu Ijiro, and Ikuo Suemune
Appl. Phys. Express, 2013, 6, 062801

Gold Nanoparticles as a Vaccine Platform: Influence of Size and Shape on Immunological Responses in Vitro and in Vivo
Kenichi Niikura, Tatsuya Matsunaga, Tadaki Suzuki, Shintaro Kobayashi, Hiroki Yamaguchi, Yasuko Orba, Akira Kawaguchi, Hideki Hasegawa, Kiichi Kajino, Takafumi Ninomiya, Kuniharu Ijiro, and Hirofumi Sawa
ACS Nano, 2013, 7, 3926–3938

Sub-100 nm Gold Nanoparticle Vesicles as a Drug Delivery Carrier enabling Rapid Drug Release upon Light Irradiation
K. Niikura, N. Iyo, Y. Matsuo, H. Mitomo, and K. Ijiro
ACS Appl. Mater. Interfaces, 2013, 5, 3900–3907

Virus-Like Particles with Removable Cyclodextrins Enable Glutathione-Triggered Drug Release in Cells
K. Niikura, N, Sugimura, Y. Musashi, S, Mikuni, Y. Matsuo, S. Kobayashi, K. Nagakawa, S. Takahara, C. Takeuchi, H. Sawa, M. Kinjo, K. Ijiro
Mol. BioSyst. 2013, 9, 501-507


Nanopattern Fabrication of Gold on Hydrogels and Application to Tunable Photonic Crystal
N. Shimamoto, Y. Tanaka, H. Mitomo, R. Kawamura, K. Ijiro, K. Sasaki, Y. Osada
Adv. Mater. 2012, 24, 5243-5248

Sequence-Specific Metallization of Single Divalent DNA–Nanoparticle Conjugates: A Potential Route to Single-Electron Devices
G. Wang, A. Ishikawa, A. Eguchi, Y. Suzuki, S. Tanaka, Y. Matsuo, K. Niikura, K. Ijiro
ChemPlusChem 2012, 77, 592

Hydrophilic Double-Network Polymers that Sustain High Mechanical Modulus under 80% Humidity
T. Tominaga, K. Sano, J. Kikuchi, H. Mitomo, K. Ijiro, Y. Osada
ACS Macro Lett. 2012, 1, 432

Novel charge transports in DNA-templated nanowires
G. Wang, H. Tanaka, L. Hong, Y. Matsuo, K. Niikura, M. Abe, K. Matsumoto, T. Ogawa, K. Ijiro
J. Mater. Chem. 2012, 22, 13691-13697

Gold Nanoparticles Coated with Semi-Fluorinated Oligoethyleneglycol Produce sub-100 nm Nanoparticle Vesicles without Templates
K. Niikura, N. Iyo, T. Higuchi, T. Nishio, H. Jinnai, N. Fujitani, K. Ijiro
J. Am. Chem. Soc. 2012, 134, 7632

Hydrophilic Gold Nanoparticles Adaptable for Hydrophobic Solvents
S. Sekiguchi, K. Niikura, Y. Matsuo, K. Ijiro
Langmuir 2012, 28, 5503-5507

Nuclear Transport facilitated by the Interaction Between Nuclear Pores and Carbohydrates
S. Sekiguchi, K. Niikura, Y. Matsuo, Shige H. Yoshimura, K. Ijiro
RSC Advances 2012, 2, 1656-1662

Virus Capsid Coating of Gold Nanoparticles via Cysteine-Au Interactions and their Effective Cellular Uptakes
K. Nagakawa, K. Niikura, T. Suzuki, Y. Matsuo, M. Igarashi, H. Sawa, K. Ijiro
Chem. Lett. 2012, 41, 113-115


pH-Dependent Network Formation of Quantum Dots and Fluorescent Quenching by Au Nanoparticle Embedding
S. Sekiguchi, K. Niikura, N. Iyo, Y. Matsuo, A. Eguchi, T. Nakabayashi, N. Ohta, K. Ijiro
ACS Applied Materials & Interfaces 2011, 3, 4169–4173

Inspiration from chemical photography: accelerated photoconversion of AgCl to functional silver nanoparticles mediated by DNA
G. Wang, T. Nishio, M. Sato, A. Ishikawa,K. Nambara, K. Nagakawa, Y. Matsuo, K. Niikura and K. Ijiro
Chem. Commun. 2011, 47, 9426-9428

Thermoresponsive Microtubule Hydrogel with High Hierarchical Structure
K. Sano, R. Kawamura, T. Tominaga, H. Nakagawa, N. Oda, K. Ijiro, and Y. Osada
Biomacromolecules 2011, 12, 1409-1413

Improving in vivo hepatic transfection activity by controlling the intracellular trafficking; the function of GALA and maltotriose
H. Akita , T. Masuda , T. Nishio , K. Niikura , K. Ijiro , and H. Harashima
Mol. Pharmaceutics 2011, 8, 1436-1442

Artificial polymeric receptors on the cell surface promote the efficient cellular uptake of quantum dots
K. Niikura, K. Nambara, T. Okajima, R. Kamitani, S. Aoki, Y. Matsuo, and K. Ijiro
Organic and Biomolecular Chemistry 2011, 9, 5787-5792


Self-lubricating nanoparticles: self-organization into 3D-superlattices during a fast drying process
T. Nishio, K. Niikura, Y. Matsuo, K. Ijiro
Chem. Commun. 2010, 46, 8977-8979

Influence of Hydrophobic Structures on the Plasma Membrane Permeability of Lipidlike Molecules
K. Niikura, K. Nambara, T. Okajima, Y. Matsuo, K. Ijiro
Langmuir 2010, 26, 9170-9175

Low pH-Triggered Model Drug Molecule Release from Virus-Like Particles
N. Ohtake, K. Niikura, T. Suzuki, K. Nagakawa, S. Mikuni, Y. Matsuo, M. Kinjo, H. Sawa, K. Ijiro
ChemBioChem 2010, 11, 959-962


Multivalent display of oligosaccharides on nanoparticles accelerates their nuclear import
K. Niikura, K. Ijiro, S. Sekiguchi
TIGG 2009, 21, 335-344

Design of cell surface-retained polymers for artificial ligand display
R. Kamitani, K. Niikura, T. Okajima, Y. Matsuo, K. Ijiro
ChemBioChem 2009, 10, 230-233

Gold Nanoparticle Arrangement on Viral Particles through Carbohydrate Recognition: A Non-Cross-Linking Approach to Optical Virus Detection
K. Niikura, K. Nagakawa, N. Ohtake, T. Suzuki, Y. Matsuo, H. Sawa, K. Ijiro
Bioconjugate Chem. 2009, 20, 1848-1852

Enhanced Accumulation of Carcohydrate-displaying CdTe Quantum Dots in Cells Responding to Cellular Chemical Stresses
T. Nishio, K. Niikura, Y. Matsuo, K. Ijiro
Int. J. Nanosci. 2009, 8, 219-222

Envelope-type lipid nanoparticles incorporating a short PEG-lipid conjugate for improved control of intracellular trafficking and transgene transcription
T. Masuda,H. Akita, K. Niikura, T. Nishio, M. Ukawa, K. Enoto, R. Danev, K. Nagayama, K. Ijiro, H. Harashima
Biomaterials 2009, 30, 4806-4814

Original papers prior to papers avobe, please click here.