Bioorganisms are capable of efficient energy transformation, selective syntheses of biomolecules and interactive information processing. All these processes are based on effective molecular recognition at highly organized supramolecular assemblies. Our research group is concerned with the construction of hierarchical molecular devices by the combination of nanosize molecular assemblies with micron size structures derived from dissipative processes. The following themes are in progress.
(1) DNA (deoxyribonucleotides) brush has been fabricated by the enzymatic polymerization of oligonucleotides immobilized on the substrate. This can be superior adhesive substrate with high selectivity.
(2) Protein-assemblies using virus-capsid proteins have been explored. Chemical modification of the proteins can give the inclusion and stimulus responsive release of drugs to the virus capsules. This can be suited for the drug delivery carrier.
(3) Metal nanoparticles-assembly by surface modification has been studied. Assembled metal nanoparticles can be applied to chemical sensors or drug delivery carriers.
These researches aim to develop functional molecular devices such as chemical sensors, cell culture substrate, virus-based drug delivery carries.
* Creation of the DNA brush as superior substrates
* Fabrication of virus-based drug delivery systems
* Development of metal nanoparticles assemblies by surface modifications
* Development of functional gels with excellent mechanical or optical characteristics