北海道大学電子科学研究所 生体分子デバイス研究分野

2015

Synthesis of Janus-Like Gold Nanoparticles with Hydrophilic/Hydrophobic Faces by Surface Ligand Exchange and Their Self-Assemblies in Water
Ryo Iida, Hitoshi Kawamura, Kenichi Niikura, Takashi Kimura, Shota Sekiguchi, Yasumasa Joti, Yoshitaka Bessho, Hideyuki Mitomo, Yoshinori Nishino, and Kuniharu Ijiro
Langmuir 2015, 31, 4054-4062

Encapsulation of a Gold Nanoparticle in a DNA Origami Container
Akinori Kuzuya, Yuichi Ohya , Masafumi Kaino, Mirai Hashizume, Kazuki Matsumoto
Takeaki Uehara, Yasutaka Matsuo, Hideyuki Mitomo, Kenichi Niikura, Kuniharu Ijiro, Yuichi Ohya
Polymer Journal 2015, 47, 177-182

Enzymatic Synthesis of a DNA Triblock Copolymer that is Composed of Natural and Unnatural Nucleotides
Hideyuki Mitomo, Yukie Watanabe, Yasutaka Matsuo, Kenichi Niikura, Kuniharu Ijiro
Chem. Asian. J. 2015, 10, 455–460

2014

Amphiphilic Gold Nanoparticles Displaying Flexible Bifurcated Ligands as a Carrier for siRNA Delivery into the Cell Cytosol
Kenichi Niikura, Kenya Kobayashi, Chie Takeuchi, Naoki Fujitani, Shuko Takahara,
Takafumi Ninomiya, Kyoji Hagiwara, Hideyuki Mitomo, Yoshihiro Ito, Yoshihito Osada,
Kuniharu Ijiro
ACS Appl. Mater. Interfaces 2014, 6, 22146–22154

Enhanced Cellular Uptake of Amphiphilic Gold Nanoparticles with Ester Functionality
Kenya Kobayashi, Kenichi Niikura, Chie Takeuchi, Shota Sekiguchi, Takafumi Ninomiya, Kyoji Hagiwara, Hideyuki Mitomo, Yoshihiro Ito, Yoshihito Osada and Kuniharu Ijiro
Chem. Commun. 2014, 50, 1265-1267

Chemically cross-linked microtubule assembly shows enhanced dynamic motions on kinesins
Ryuzo Kawamura, Ken-Ichi Sano, Kuniharu Ijiro, and Yoshihito Osada
RSC Advances 2014, 4, 32953-32959

2013

Water transport mechanism through open capillaries analyzed by direct surface modifications on biological surfaces
Daisuke Ishii, Hiroko Horiguchi, Yuji Hirai, Hiroshi Yabu, Yasutaka Matsuo, Kuniharu Ijiro, Kaoru Tsujii, Tateo Shimozawa, Takahiko Hariyama & Masatsugu Shimomura
Scientific Reports20133, 3024

Cysteine Residues in the Major Capsid Protein, Vp1, of the JC Virus Are Important for Protein Stability and Oligomer Formation
S. Kobayashi, T. Suzuki, M. Igarashi, Y. Orba, N. Ohtake, K. Nagakawa, K. Niikura, T. Kimura, H. Kasamatsu, and H. Sawa
PLOS ONE20138(10), e76668

DNA-templated plasmonic Ag/AgCl nanostructures for molecular selective photocatalysis and photocatalytic inactivation of cancer cells
G. Wang, H. Mitomo, Y. Matsuo, N. Shimamoto, K. Niikura, and K. Ijiro
Journal of Materials Chemistry B20131, 5899

「塩基配列選択的な金属化によるナノギャップ構造形成に向けた鋳型DNAの作製」
三友秀之・渡辺雪江・松尾保孝・新倉謙一・居城邦治
高分子論文集, 70(7), 337-340 (2013)

Enhanced Photon Extraction from a Quantum Dot Induced by a Silver Microcolumnar Photon Reflector
Hidekazu Kumano, Hideaki Nakajima, Hitoshi Iijima, Satoru Odashima, Yasuhiro Matsuo, Kuniharu Ijiro, and Ikuo Suemune
Appl. Phys. Express20136, 062801

Gold Nanoparticles as a Vaccine Platform: Influence of Size and Shape on Immunological Responses in Vitro and in Vivo
Kenichi Niikura, Tatsuya Matsunaga, Tadaki Suzuki, Shintaro Kobayashi, Hiroki Yamaguchi, Yasuko Orba, Akira Kawaguchi, Hideki Hasegawa, Kiichi Kajino, Takafumi Ninomiya, Kuniharu Ijiro, and Hirofumi Sawa
ACS Nano20137, 3926–3938

Sub-100 nm Gold Nanoparticle Vesicles as a Drug Delivery Carrier enabling Rapid Drug Release upon Light Irradiation
K. Niikura, N. Iyo, Y. Matsuo, H. Mitomo, and K. Ijiro
ACS Appl. Mater. Interfaces20135, 3900–3907

Virus-Like Particles with Removable Cyclodextrins Enable Glutathione-Triggered Drug Release in Cells
K. Niikura, N, Sugimura, Y. Musashi, S, Mikuni, Y. Matsuo, S. Kobayashi, K. Nagakawa, S. Takahara, C. Takeuchi, H. Sawa, M. Kinjo, K. Ijiro
Mol. BioSyst. 20139, 501-507

2012

Nanopattern Fabrication of Gold on Hydrogels and Application to Tunable Photonic Crystal
N. Shimamoto, Y. Tanaka, H. Mitomo, R. Kawamura, K. Ijiro, K. Sasaki, Y. Osada
Adv. Mater. 201224, 5243-5248

Sequence-Specific Metallization of Single Divalent DNA–Nanoparticle Conjugates: A Potential Route to Single-Electron Devices
G. Wang, A. Ishikawa, A. Eguchi, Y. Suzuki, S. Tanaka, Y. Matsuo, K. Niikura, K. Ijiro
ChemPlusChem 201277, 592

Hydrophilic Double-Network Polymers that Sustain High Mechanical Modulus under 80% Humidity
T. Tominaga, K. Sano, J. Kikuchi, H. Mitomo, K. Ijiro, Y. Osada
ACS Macro Lett. 20121, 432

Novel charge transports in DNA-templated nanowires
G. Wang, H. Tanaka, L. Hong, Y. Matsuo, K. Niikura, M. Abe, K. Matsumoto, T. Ogawa, K. Ijiro
J. Mater. Chem. 201222, 13691-13697

Gold Nanoparticles Coated with Semi-Fluorinated Oligoethyleneglycol Produce sub-100 nm Nanoparticle Vesicles without Templates
K. Niikura, N. Iyo, T. Higuchi, T. Nishio, H. Jinnai, N. Fujitani, K. Ijiro
J. Am. Chem. Soc. 2012134, 7632

Hydrophilic Gold Nanoparticles Adaptable for Hydrophobic Solvents
S. Sekiguchi, K. Niikura, Y. Matsuo, K. Ijiro
Langmuir 201228, 5503-5507

Nuclear Transport facilitated by the Interaction Between Nuclear Pores and Carbohydrates
S. Sekiguchi, K. Niikura, Y. Matsuo, Shige H. Yoshimura, K. Ijiro
RSC Advances 20122, 1656-1662

Virus Capsid Coating of Gold Nanoparticles via Cysteine-Au Interactions and their Effective Cellular Uptakes
K. Nagakawa, K. Niikura, T. Suzuki, Y. Matsuo, M. Igarashi, H. Sawa, K. Ijiro
Chem. Lett. 201241, 113-115

2011

pH-Dependent Network Formation of Quantum Dots and Fluorescent Quenching by Au Nanoparticle Embedding
S. Sekiguchi, K. Niikura, N. Iyo, Y. Matsuo, A. Eguchi, T. Nakabayashi, N. Ohta, K. Ijiro
ACS Applied Materials & Interfaces 20113, 4169–4173

Inspiration from chemical photography: accelerated photoconversion of AgCl to functional silver nanoparticles mediated by DNA
G. Wang, T. Nishio, M. Sato, A. Ishikawa,K. Nambara, K. Nagakawa, Y. Matsuo, K. Niikura and K. Ijiro
Chem. Commun. 201147, 9426-9428

Thermoresponsive Microtubule Hydrogel with High Hierarchical Structure
K. Sano, R. Kawamura, T. Tominaga, H. Nakagawa, N. Oda, K. Ijiro, and Y. Osada
Biomacromolecules 201112, 1409-1413

Improving in vivo hepatic transfection activity by controlling the intracellular trafficking; the function of GALA and maltotriose
H. Akita , T. Masuda , T. Nishio , K. Niikura , K. Ijiro , and H. Harashima
Mol. Pharmaceutics 20118, 1436-1442

Artificial polymeric receptors on the cell surface promote the efficient cellular uptake of quantum dots
K. Niikura, K. Nambara, T. Okajima, R. Kamitani, S. Aoki, Y. Matsuo, and K. Ijiro
Organic and Biomolecular Chemistry 20119, 5787-5792

2010

Self-lubricating nanoparticles: self-organization into 3D-superlattices during a fast drying process
T. Nishio, K. Niikura, Y. Matsuo, K. Ijiro
Chem. Commun. 201046, 8977-8979

Influence of Hydrophobic Structures on the Plasma Membrane Permeability of Lipidlike Molecules
K. Niikura, K. Nambara, T. Okajima, Y. Matsuo, K. Ijiro
Langmuir 201026, 9170-9175

Low pH-Triggered Model Drug Molecule Release from Virus-Like Particles
N. Ohtake, K. Niikura, T. Suzuki, K. Nagakawa, S. Mikuni, Y. Matsuo, M. Kinjo, H. Sawa, K. Ijiro
ChemBioChem 201011, 959-962

2009

Multivalent display of oligosaccharides on nanoparticles accelerates their nuclear import
K. Niikura, K. Ijiro, S. Sekiguchi
TIGG 200921, 335-344

Design of cell surface-retained polymers for artificial ligand display
R. Kamitani, K. Niikura, T. Okajima, Y. Matsuo, K. Ijiro
ChemBioChem 200910, 230-233

Gold Nanoparticle Arrangement on Viral Particles through Carbohydrate Recognition: A Non-Cross-Linking Approach to Optical Virus Detection
K. Niikura, K. Nagakawa, N. Ohtake, T. Suzuki, Y. Matsuo, H. Sawa, K. Ijiro
Bioconjugate Chem. 200920, 1848-1852

Enhanced Accumulation of Carcohydrate-displaying CdTe Quantum Dots in Cells Responding to Cellular Chemical Stresses
T. Nishio, K. Niikura, Y. Matsuo, K. Ijiro
Int. J. Nanosci. 20098, 219-222

Envelope-type lipid nanoparticles incorporating a short PEG-lipid conjugate for improved control of intracellular trafficking and transgene transcription
T. Masuda,H. Akita, K. Niikura, T. Nishio, M. Ukawa, K. Enoto, R. Danev, K. Nagayama, K. Ijiro, H. Harashima
Biomaterials 200930, 4806-4814

Original papers prior to papers avobe, please click here.